• Herbicide

The new standard in mesquite control

Sendero® herbicide is the new standard in mesquite control, offering greater than 15 percent better control and more consistency than the old standard. Sendero does not harm grasses and many desirable brush species. Controlling mesquite with Sendero results in increased grass production and improved wildlife habitat.

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Minimal nontarget tree injury

Sendero® herbicide not only increases honey mesquite control but also exhibits minimal nontarget tree effects. Early data collection indicates that Sendero causes only minor or no injury to important livestock and wildlife tree species.

Improved, consistent control

Sendero provides improved and more consistent control of mesquite, compared with the old standard of Remedy® Ultra plus Reclaim® herbicide.1


1Cummings, D. C., Langston, V. B., and Burch, P. L. 2012. GF 2791 (Sendero), a new herbicide containing aminopyralid and clopyralid, for honey mesquite (Prosopis glandulosa) control in southwestern rangelands. Technical Presentation, 65th Annual Meeting and Trade Show of the Society for Range Management, Spokane, Was

Enhanced livestock grazing and wildlife habitat

Sendero offers best-in-class grass safety and has minimal impact on desirable forbs and certain wildlife browse species. Sendero controls mesquite but leaves behind guayacan, pricklypear, tasajillo, cenizo, torrey croton, leatherstem, coyotillo, oreganillo, riogrande beebrush and elbowbush. Sendero causes short-term canopy reduction on guajillo and kidneywood.

Use sites

Conservation Reserve Program Acres

Habitat Management Areas

Natural Areas

Nonplanted/Noncrop Areas


Prairie Management


Wildlife Openings

Wildlife Habitat

Controlled weeds

This product delivers effective weed control against the following:

  • Annual broomweed
  • Black Locust
  • Cocklebur
  • Coffeeweed
  • Common Ragweed
  • Honey Locust
  • Honey Mesquite
  • Lambert Locoweed
  • Mimosa
  • Silverleaf Nightshade
  • Western Ragweed
  • Woolly Locoweed

Refer to the Product Label for complete product efficacy information.

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State registrations

  • Registered
  • Unregistered

Technical Specifications

  • Active Ingredient

    Potassium salt of 2-pyridine carboxylic acid, 4-amino-3,6-dichloro-; Monoethanolamine salt of 3,6-dichloro-2-pyridinecarboxylic acid

  • Application Rate

    See product specimen label for specific rate recommendations.

  • Application Timing

    Proper conditions required for acceptable honey mesquite control with herbicide applications:

    • Proper application window (40 to 90 days post bud break)
    • Soil temperatures higher than 75 F at 12 inches below soil surface in the shade
    • Mesquite leaf condition good, with only dark green growth indicating mature foliage
    • Minimal insect, rodent and weather injury to leaves and trees
    • Soil moisture through the season that is adequate for proper leaf development
  • Application Method

    Aerial broadcast. Ground broadcast. High-volume foliar/leaf spray.

Timing is Key for Controlling Mequite


Sendero herbicide has proven to be more consistent and more efficacious than a mixture of Remedy® Ultra and Reclaim® herbicides.1 But even with this effective tool for mesquite control, land managers and applicators still need to make applications at the right times.

To control mesquite with Sendero, or any herbicide, soil temperature should be at least 75 F. Avoid treating in low humidity, during drought stress or after a big rain following a dry period. Avoid spraying during active bean elongation of mesquite trees.

1Cummings, D. C., V. B. Langston, and P. L. Burch. 2012. GF-2791 [Sendero], a new herbicide containing aminopyralid and clopyralid, for honey mesquite (Prosopis glandulosa) control in southwestern rangelands. Technical Presentation, 65th Annual Meeting and Trade Show of the Society for Range Management, Spokane, Wash.

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Label precautions apply to forage treated with GrazonNext HL and to manure from animals that have consumed treated forage within the last three days. Consult the label for full details.

™ ® Trademarks of Corteva Agriscience and its affiliated companies. MezaVue is a Restricted Use Pesticide. GrazonNext HL, MezaVue and Sendero are not registered for sale or use in all states. Contact your state pesticide regulatory agency to determine if a product is registered for sale or use in your state. State restrictions on the sale and use of Remedy Ultra apply. Consult the label before purchase or use for full details. Always read and follow label directions. Patent Pending. © 2021 Corteva.

Sendero is covered by U.S. Patent No. 10,412,964 and other pending U.S. patent applications, international patents, and pending international patent applications.